Cannabinoids & Your Period

  • 9 Comments
  • Should I take CBD oil for period cramps?
  • How do CBD and ibuprofen compare?
  • How can I get the best benefits from CBD oil for my period?

It’s that time of the month again — time to call in sick, cancel plans, curl up in bed with a hot water bottle, and try to distract yourself with a non-stop stream of movies and TV.

If this sounds like your monthly ritual, you are not alone. Up to 90% of reproductive-age women suffer from painful periods — the medical term for it is “dysmenorrhea” — and it can completely derail your daily life.

Cannabinoids & Suppositories Help

More and more women are reporting that CBD and THC products are the best tools they have for treating painful periods. But how do they stack up when compared to NSAIDs like Ibuprofen?

Quite well, it turns out, but it’s worth a deeper look at why they work — exactly how cannabinoids’ anti-inflammatory, pain-relieving, muscle-relaxing effects interact with your period.

This touches on the actual causes of pain & discomfort during your period, and how additional natural remedies can help combat these symptoms.

Move over NSAIDs and heating pads! Read on to discover why cannabinoids might become your new favorite companion when your period comes to town...

Your Uterus: Prepping for a Visit

In people who have periods, the uterus diligently prepares itself all month.

First, your body’s increasing estrogen told your uterus to build up its endometrial tissue. Then, after you ovulated, and the boost of progesterone helped plump up that tissue with arteries and blood — prepping to give a warm welcome to an incoming embryo … or in this case to prepare for menstruation.

Goodbye, Progesterone

Once your body discovers it won’t be hosting a guest, your progesterone levels decline — telling your uterus to roll up the welcome mat.

Your body takes back what it can from the endometrium, shrinking the tissue and cutting off blood flow to its spiral-shaped arteries. Without a proper blood supply, your endometrial tissue prepares to shed, and you likely begin experiencing pangs of pain.

Without progesterone, the endometrium loses its protection – creating a domino effect, and the perfect conditions for inflammation.

Prostaglandins: Inflaming the Uterus

While your progesterone was declining, inflammatory chemicals called prostaglandins were increasing. Prostaglandins (particularly one called PGF2⍺) peak during menstruation, creating the following effects:

  • Inflammation: certain prostaglandins trigger an inflammatory response, which leads to more pain.
  • Pain sensitization: prostaglandins and other inflammatory compounds can actually prime pain-perceiving nerves to become more sensitive.
  • Vasoconstriction: the prostaglandins rampant during menstruation cause blood vessels to constrict, inhibiting blood flow to the endometrial tissue.
  • Uterine contractions: People with higher prostaglandin levels have stronger, more painful contractions and doctors are finally acknowledging that this pain can be as intense as heart attack pain.
  • Heavy bleeding: Unusually heavy periods could result from excessive inflammation, which increases tissue damage. People with heavy bleeding have higher levels of the enzyme the produces prostaglandins (COX-2), and medications to combat this process can decrease menstruation.
  • Diarrhea: In addition to uterus contractions, prostaglandins also trigger smooth muscle contractions in the digestive tract — which might push your last few meals out a bit too soon.

(Note: some people claim that having sex helps to jump-start their periods — scientists believe that the prostaglandins in semen could contribute to this effect.)

We’re not trying to say that prostaglandins are all bad. They're essential for a healthy, functioning menstrual cycle.

However, numerous studies indicate that women with higher levels of prostaglandins also have more painful or heavier periods — and treatments that lower prostaglandin levels can be highly effective.

NSAIDs Work, Sort Of

When their periods kick in, most women reach for an Ibuprofen or similar NSAID (Non Steroidal Anti-Inflammatory Drug). Why are NSAIDs the most frequently-prescribed treatment for menstrual pain?

NSAIDs work by inhibiting the enzyme responsible for producing prostaglandins (COX-2). This means that NSAIDs could potentially decrease all the symptoms aggravated by prostaglandins — including inflammation, contractions and pain.

Unfortunately, NSAIDs can also have unpleasant gastrointestinal side effects, because they inhibit another enzyme (COX-1). For this reason, NSAIDs should be used with moderation, and people with certain digestive issues might want to avoid them entirely.

CBD: a Better Alternative?

Recently, scientists discovered that — similar to NSAIDs — CBD also inhibits the prostaglandin-producing enzyme. However — unlike NSAIDs — CBD preferentially inhibits COX-2 over COX-1, which means its anti-inflammatory benefits come without the gastrointestinal side effects.

Added bonus: Not only does CBD inhibit the COX-2 enzyme, but both CBD and THC physically stop your DNA from producing so much of this enzyme in the first place (via the PPARγ receptor).

Additional Cannabinoid Benefits

By decreasing prostaglandin levels during your period, you can reduce inflammation, pain and cramps. However, you cannot entirely eliminate prostaglandins.

This means that you could benefit from combining a prostaglandin-reducing treatment with other treatments that target the discomforts caused by prostaglandins.

CBD and other cannabinoids can also treat painful menstrual cramps in the following ways:

  • Anti-inflammatory: Cannabinoids have many anti-inflammatory activities beyond reducing production of inflammatory prostaglandins. For instance, THC activates endocannabinoid receptors (CB2) located on your immune system’s killer cells (macrophages). When these receptors are activated, they prevent macrophages from releasing inflammatory proteins (cytokines).
  • Pain-relieving: Although prostaglandins and other inflammatory molecules can make pain-perceiving nerves more sensitive, cannabinoids fight back by desensitizing these nerves. Both CBD and THC target nerve receptors that help decrease the sensation of pain (TRPV1 and CB1, respectively). Additionally, not only does CBD desensitize TRPV1, but those soothing effects can spread to neighboring pain receptors.
  • Muscle-relaxing: Menstrual cramps are exacerbated by contractions of the smooth muscle lining the uterus — and cannabinoids are widely recognized to relax smooth muscles. THC and CBD both target different receptors embedded in the muscle tissue to relax contractions.
  • Vascular-relaxing: Blood vessels are also lined with smooth muscle, and when cannabinoids trigger this smooth muscle to relax, blood flow increases. Increased blood flow could help provide relief to oxygen-starved tissues, further decreasing painful cramps.

Natural Remedies for Cramps

  • Apply heat: Hot water bottles may seem old-fashioned, but they can bring as much relief from menstrual cramps as NSAIDs — and oftentimes much faster. Heat increases blood flow to the area, which soothes the overworked muscles and delivers oxygen to oxygen-starved tissues. Some scientists also think that heat desensitizes the same pain receptors that CBD works on.
  • Fish oil: Interestingly enough, multiple studies have demonstrated that daily fish oil supplements decrease pain and reliance on NSAIDs during periods. It turns out that prostaglandins are synthesized from omega fatty acids, and a diet high in omega-3 fatty acids could shift your body away from producing inflammatory prostaglandins.
  • Magnesium: Do you ever crave chocolate around this time of the month? Women who take magnesium supplements during their periods have reduced pain and reduced inflammatory prostaglandin levels. Foods like chocolate, lentils and avocados are high in magnesium — so go ahead and feed the craving.
  • Treat early: Many doctors suggest that it’s best to start taking painkillers an hour or more before the cramps start. This is true whether you’re using NSAIDs, CBD, or other cannabinoid blends. If you hold off treatment until you’re in excruciating pain, the prostaglandins will already be in full demolition mode and harder to bring under control.
  • Discuss your treatment plan with a doctor: Sometimes painful cramps and/or heavy bleeding can be a symptom of an underlying problem like endometriosis (another painful condition that can be soothed by cannabinoids). We encourage you to talk with your doctor about your symptoms and treatment plan in order to rule out other health problems, particularly if your symptoms don’t improve with standard treatments. Your doctor can help you determine if there are surgical or hormonal treatments that could be more effective.

Finding Relief With Cannabinoid Suppositories

Many women are shocked and surprised to experience how effective cannabinoids are at relieving menstrual cramps (especially cannabinoid suppositories).

But the science is pretty clear about why: CBD targets the cause — inflammatory prostaglandins — while also relieving the symptoms (especially with help from a little THC).

Perhaps this is why women and people who bleed have been using cannabis to treat period pain for millennia. Though there are increasing numbers of doctors and scientists who know why cannabinoids work to relieve menstrual cramps, many more of them are only just beginning to hear from their female patients about how well cannabinoids work for their periods.

If you’re considering treating your menstrual cramps with cannabinoids for the first time, we encourage you to read testimonials from other customers. You may also be curious to know how cannabinoids help to soothe endometriosis.

And if “weed tampons” aren’t available in your city or state, try our CBD Suppositories which are now available online and ship world-wide.


More articles by: Genevieve R. Moore PhD



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9 Comments

  • I have endometriosis and recently started using these. My life has been changed because of these. I recommend them to everyone all the time! My heartfelt thank you to the company ❤️ living life again ❤️

    Lillie on
  • I have endometriosis and recently started using these. My life has been changed because of these. I recommend them to everyone all the time! My heartfelt thank you to the company ❤️ living life again ❤️

    Lillie on
  • Hey! Really Informative blog. I just want to add another benefits of Cannabis for PMS. Headaches are also the most common problem that women suffer during PMS.Research suggests that cannabis may help alleviate them too.Cannabis can help reduce monthly migraines. We all know that cannabis affects our mood. And when it comes to PMS, that can be a really good thing. The changes that take place in a woman’s body during or before menstruation often cause strong mood swings that can be difficult to control. In fact, studies show that cannabis may help people dealing with the emotional stress of mental issues such as anxiety and depression.
    I hope the information will be useful to your readers.

    Online Medical Card Fountain Valley on
  • Great blog! Thanks for sharing such an useful post for us. Keep up the good work!

    Walter Chapman on
  • Thanks for sharing your comments & questions, all :)

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    —Breast-feeding:
    We personally feel comfortable using CBD with our own kids, but absolutely insist that you consult with your pediatric specialist or OBGYN. Feel free to share the following articles with your doctor (the research links are informative):
    https://www.foriawellness.com/blogs/learn/your-endocannabinoid-system-cbd
    https://www.foriawellness.com/blogs/learn/cannabinoids-your-period

    Foria on
  • What is the best product for post menopausal pain during sex? Haven’t had sex with my husband for two years because of pain. Help.

    Patricia on
  • How to sensibly buy LEGAL CBD oil? Because I got a letter saying customs have confiscated my package two times already and I’m pissed.

    Allison C on
  • I love the way you wrote in the beginning of the article…. doubled over in pain you made me smile :-) very interested in trying cbd for these awful cramps. Is it safe while breastfeeding? Thank you

    Mandi on
  • I will try almost anything for painful periods. Are the “weed tampons” available yet? I’d love to take part in the trials.

    Connie on

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